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Nelotanserin

Cat. No. M13871

All AbMole products are for research use only, cannot be used for human consumption.

Nelotanserin Structure
Synonym:

APD125

Size Price Availability Quantity
1mg USD 45  USD45 In stock
5mg USD 90  USD90 In stock
10mg USD 140  USD140 In stock
25mg USD 240  USD240 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.

Chemical Information
Molecular Weight 437.24
CAS Number 839713-36-9
Solubility (25°C) DMSO ≥ 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ambra Stefani, et al. Nelotanserin as symptomatic treatment for rapid eye movement sleep behavior disorder: a double-blind randomized study using video analysis in patients with dementia with Lewy bodies or Parkinson's disease dementia

[2] Latha Velayudhan, et al. New Therapeutic Strategies for Lewy Body Dementias

[3] Philippe Huot, et al. Serotonergic Approaches in Parkinson's Disease: Translational Perspectives, an Update

[4] Jaime M Monti. Serotonin control of sleep-wake behavior

[5] Hussien A Al-Shamma, et al. Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia

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Keywords: Nelotanserin, APD125 supplier, 5-HT Receptor, inhibitors, activators

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