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Paroxetine

Cat. No. M10054
Paroxetine Structure
Size Price Availability Quantity
10mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Paroxetine is a inhibitor of serotonin uptake.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 329.37
Formula C19H20FNO3
CAS Number 61869-08-7
Purity >99%
Solubility
Storage at -20°C
References

[1] Anick Berard, et al. Br J Clin Pharmacol. The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis

[2] Marianna Purgato, et al. Cochrane Database Syst Rev. Paroxetine versus other anti-depressive agents for depression

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