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Fluoxetine

Cat. No. M14577

All AbMole products are for research use only, cannot be used for human consumption.

Fluoxetine Structure
Synonym:

LY-110140 free base

Size Price Availability Quantity
100mg USD 80  USD80 In stock
500mg USD 180  USD180 In stock
1g USD 240  USD240 In stock
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Biological Activity

Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex.

Product Citations
Chemical Information
Molecular Weight 309.33
Formula C17H18F3NO
CAS Number 54910-89-3
Form Liquid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ahmed Barakat, et al. Uses of fluoxetine in nociceptive pain management: A literature overview

[2] Jing-Wen Wang, et al. J Neurosci. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells

[3] Masafumi Kodama, et al. Biol Psychiatry. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat

[4] Jessica E Malberg, et al. Neuropsychopharmacology. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment

[5] Frank P Bymaster, et al. Psychopharmacology (Berl). Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex

[6] W Zhang, et al. Neuropsychopharmacology. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex

[7] P Benfield, et al. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness

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Keywords: Fluoxetine, LY-110140 free base supplier, 5-HT Receptor, inhibitors, activators

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