Free shipping on all orders over $ 500


Cat. No. M10345
Eucalyptol Structure


Size Price Availability Quantity
1mL USD 50  USD50 In stock
10mL USD 90  USD90 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Eucalyptol is an inhibitor of 5-HT3 receptor, potassium channel, with anti-inflammatory and antioxidant activities. In addition, eucalyptol shows neuroprotective effects in ischemic stroke models, anti-inflammatory effects in neurodegenerative diseases such as Alzheimer's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 154.25
Formula C10H18O
CAS Number 470-82-6
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C, dry, sealed

[1] Germana Freire Rocha Caldas, et al. Food Chem Toxicol. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats

[2] Gavin E Jarvis, et al. J Pharmacol Exp Ther. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling

[3] Zahra Zeraatpisheh, et al. Eur J Pharmacol. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels

[4] Andleeb Khan, et al. Neurochem Res. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease

Related 5-HT Receptor Products
Alniditan dihydrochloride

Anidetam dihydrochloride Alniditan (Alnitidan) dihydrochloride is an effective one 5-HT1B and 5-HT1D RECEPTOR AGONISTS, IN HEK 293 CELLS, IN HUMANS 5-HT1B and people 5-HT1D receptors IC50 1.7 nM and 1.3 nM, respectively. Alniditan dihydrochloride has the effect of preventing migraines.

NLX-101 (F-15599)

NLX-101 (F-15599) is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM. NLX-101 (F-15599) mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors. NLX-101 (F-15599) has over 1000-fold higher affinity for this target over other receptors.


Lasmiditan (COL-144; LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist, showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor in vitro binding studies.


Paroxetine is a inhibitor of serotonin uptake.


AVN-492 is a potent and selective 5-HT6R antagonist, binds to 5-HT6R (Ki = 91 pM).

Abmole Inhibitor Catalog 2017

Keywords: Eucalyptol, 1,8-Cineole supplier, 5-HT Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.