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Eucalyptol

Cat. No. M10345
Eucalyptol Structure
Synonym:

1,8-Cineole

Size Price Availability Quantity
1mL USD 50  USD50 In stock
10mL USD 90  USD90 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Eucalyptol is an inhibitor of 5-HT3 receptor, potassium channel, with anti-inflammatory and antioxidant activities. In addition, eucalyptol shows neuroprotective effects in ischemic stroke models, anti-inflammatory effects in neurodegenerative diseases such as Alzheimer's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 154.25
Formula C10H18O
CAS Number 470-82-6
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Germana Freire Rocha Caldas, et al. Food Chem Toxicol. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats

[2] Gavin E Jarvis, et al. J Pharmacol Exp Ther. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling

[3] Zahra Zeraatpisheh, et al. Eur J Pharmacol. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels

[4] Andleeb Khan, et al. Neurochem Res. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Eucalyptol, 1,8-Cineole supplier, 5-HT Receptor, inhibitors

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