| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist. |
| M5033 | Escitalopram | Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
| M5022 | Almotriptan Malate | Almotriptan Malate is a 5-HT1B/1D-receptor agonist used for the research of migraine. |
| M4887 | Pardoprunox Hydrochloride | Pardoprunox hydrochloride (DU-126891, SME-308) is an effective agonist of partial dopamine action, corresponding to pEC50 value 8.0. It is also a partial agonist inducing [35S]GTPγS binding, corresponding to pEC50 9.2 and serotonin 5-HT1A receptor 6.3. |
| M4858 | Ipsapirone | Ipsapirone (TVX Q 7821) is a partial agonist of 5-HT1A receptor and also shows antagonism to 5-HT1A receptor. It also showed inhibition of 5-HT2 and α 1-adrenergic activity only at high doses. |
| M4367 | Xanthotoxol | Xanthotoxol (8-hydroxypsoralen) is a bioactive linear furan coumarin with strong pharmacological activities such as anti-inflammatory, antioxidant, 5-HT antagonist and neuroprotective effects. |
| M4281 | Isocorynoxeine | Isocorynoxeine, an alkaloid related to uncarline, showed a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. |
| M3997 | Nuciferine | Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
| M3791 | YM 90K hydrochloride | YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. |
| M3782 | Oxiracetam | Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats. |
| M3772 | SB242084 | SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. |
| M3670 | Metoclopramide hydrochloride | Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
| M3646 | Cyclobenzaprine hydrochloride | Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant. |
| M3583 | Urapidil hydrochloride | Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. |
| M3529 | BMY 7378 dihydrochloride | BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
| M3524 | BRL-15572 dihydrochloride | BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. |
| M3481 | WAY-100635 Maleate | WAY-100635 maleate is a potent, selective 5-HT1A receptor antagonist with an IC50 value of 0.91 nM, a Ki value of 0.39 nM, and a pIC50 of 8.87, which is more than 100-fold more selective than for use at the other 5-HT receptor subtypes and major neurotransmitter receptors. In addition, WAY-100635 maleate is a potent dopamine D4 receptor agonist. |
| M3479 | Aripiprazole | Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. Aripiprazole (OPC-14597) is a potent and high-affinity dopamine D2 receptor partial agonist. |
| M3472 | Naratriptan | Naratriptan is a compound in the triptans family that has been studied for migraine. |
| M3419 | Dapoxetine hydrochloride | Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor. |
| M3414 | Olanzapine | Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
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