| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. |
| M5400 | Alosetron Hydrochloride | Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. |
| M5369 | Fenclonine (4-Chloro-DL-phenylalanine) | Fenclonine (4-Chloro-DL-phenylalanine) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine (4-Chloro-DL-phenylalanine) acts pharmacologically to deplete endogenous levels of serotonin. |
| M5214 | Lasmiditan hydrochloride | Lasmiditan hydrochloride (also known as COL-144 and LY573144) is a high-affinity, highly selective serotonin (5-HT) 5-HT(1F) receptor agonist. |
| M5134 | WAY-181187 | Way-181187 (SAX-187) is an effective selective 5-HT6 receptor agonist with Ki of 2.2 nM and EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signaling pathways, such as cAMP, Fyn and ERK1/2 kinases, as specific agonists. |
| M5130 | Cisapride | Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. IC50 Value is 0.14 μM (EC50 for 5-HT4 receptor). |
| M5045 | Tianeptine | Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo. |
| M5044 | Tianeptine sodium salt | Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. |
| M5033 | Escitalopram | Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
| M5022 | Almotriptan Malate | Almotriptan Malate is a 5-HT1B/1D-receptor agonist used for the research of migraine. |
| M4887 | Pardoprunox Hydrochloride | Pardoprunox hydrochloride (DU-126891, SME-308) is an effective agonist of partial dopamine action, corresponding to pEC50 value 8.0. It is also a partial agonist inducing [35S]GTPγS binding, corresponding to pEC50 9.2 and serotonin 5-HT1A receptor 6.3. |
| M4858 | Ipsapirone | Ipsapirone (TVX Q 7821) is a partial agonist of 5-HT1A receptor and also shows antagonism to 5-HT1A receptor. It also showed inhibition of 5-HT2 and α 1-adrenergic activity only at high doses. |
| M4367 | Xanthotoxol | Xanthotoxol (8-hydroxypsoralen) is a bioactive linear furan coumarin with strong pharmacological activities such as anti-inflammatory, antioxidant, 5-HT antagonist and neuroprotective effects. |
| M4281 | Isocorynoxeine | Isocorynoxeine, an alkaloid related to uncarline, showed a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. |
| M3997 | Nuciferine | Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
| M3983 | Puerarin | Puerarin is a 5-HT2C receptor antagonist. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. |
| M3791 | YM 90K hydrochloride | YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. |
| M3782 | Oxiracetam | Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats. |
| M3772 | SB242084 | SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. |
| M3670 | Metoclopramide hydrochloride | Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
| M3646 | Cyclobenzaprine hydrochloride | Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant. |
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