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Fenclonine (4-Chloro-DL-phenylalanine) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine (4-Chloro-DL-phenylalanine) acts pharmacologically to deplete endogenous levels of serotonin. Fenclonine (4-Chloro-DL-phenylalanine; PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). Fenclonine inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.
| Molecular Weight | 199.63 |
| Formula | C9H10ClNO2 |
| CAS Number | 7424-00-2 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL (ultrasonic and adjust pH to 2 with HCl) Water 4 mg/mL (ultrasonic and warming and adjust pH to 2 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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