Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
J Clin Invest. 2021 Dec 15;131(24):e151976.
Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure
Lorcaserin hydrochloride purchased from AbMole
|Solubility (25°C)||DMSO 26 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related 5-HT Receptor Products|
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MRS7925 is a 5-HT2BR antagonist (Ki: 17 nM).
|5-HT6 agonist 1
5-HT6 agonist 1 is a 5-HT6 agonist (Ki: 5 nM).
NAN-190 is a serotonin receptor 5-HT antagonist.
PNU109291 is a potent and selective 5-HT1D agonist.
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