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Lorcaserin hydrochloride

Cat. No. M2821
Lorcaserin hydrochloride Structure
Synonym:

APD356

Size Price Availability Quantity
10mg USD 77  USD77 In stock
50mg USD 230  USD230 In stock
100mg USD 410  USD410 In stock
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Quality Control & Documentation
Biological Activity

Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.

Product Citations
Chemical Information
Molecular Weight 232.15
Formula C11H14ClN.HCl
CAS Number 846589-98-8
Solubility (25°C) DMSO 26 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Andrea Cignarella, et al. Pharmacotherapy of obesity: An update

[2] Beverly G Tchang, et al. An up-to-date evaluation of lorcaserin hydrochloride for the treatment of obesity

[3] Sanjay Sharma, et al. Chemistry, Analysis, Pharmacokinetics and Pharmacodynamics Aspects of Lorcaserin, a Selective Serotonin 5-HT2C Receptor Agonist: An Update

[4] Dattatraya V Wani, et al. Liquid chromatographic separation and thermodynamic investigation of lorcaserin hydrochloride enantiomers on immobilized amylose-based chiral stationary phase

[5] Abu J M Sadeque, et al. Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation

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Keywords: Lorcaserin hydrochloride, APD356 supplier, 5-HT Receptor, inhibitors, activators


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