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SAM-315

Cat. No. M9584
SAM-315 Structure
Synonym:

WAY-255315

Size Price Availability
50mg USD 900  USD900 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SAM-31 (WAY-255315) is selective 5-Hydroxytryptamine-6 antagonists.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 392.47
Formula C21H20N4O2S
CAS Number 744218-85-7
Purity >98%
Solubility
Storage at -20°C
References

[1] Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

[2] P Chiba, et al. S-adenosylmethionine metabolism in HL-60 cells: effect of cell cycle and differentiation

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Keywords: SAM-315, WAY-255315 supplier, 5-HT Receptor, inhibitors

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