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Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy. Nuciferine inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. Nuciferine may also potentiate morphine analgesia. Nuciferine had a pharmacologic profile of action associated with dopamine-receptor blockade.
| Molecular Weight | 295.38 |
| Formula | C19H21NO2 |
| CAS Number | 475-83-2 |
| Solubility (25°C) | DMSO 3 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related 5-HT Receptor Products |
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