About 31 results found for searched term "IQ-3" (0.088 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M11008 | IQ-3 | JNK |
| IQ-3 is a specific inhibitor of the c-JNK family and is more selective for JNK3. IQ-3 for JNK1, JNK2, and JNK3 Kd The values are 0.24 μM, 0.29 μM, and 0.066 μM, respectively. | ||
| M27956 | EPI-743 | Mitochondrial Related |
| α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075 | ||
| EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. | ||
| M1641 | Quizartinib (AC220) | FLT3 |
| AC220 | ||
| Quizartinib (AC220) is a uniquely potent and selective FLT3 inhibitor. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2227 | Imiquimod | Animal Modeling |
| Aldara, R 837; IMQ | ||
| Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity. | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M3052 | TCID | Deubiquitinase |
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M11227 | FM-479 | JAK |
| Fm-479 was a negative control of FM-381 and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. | ||
| M4008 | Liquiritigenin | Estrogen Receptor |
| 4',7-Dihydroxyflavanone | ||
| Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc. | ||
| M4010 | Isoliquiritigenin | Aldose Reductase |
| GU17; ISL; Isoliquiritigen | ||
| Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. | ||
| M4710 | Shionone | NLR |
| Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. | ||
| M5196 | Spautin-1 | Autophagy |
| Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. | ||
| M5298 | NSC-144303 | Apoptosis |
| Ubiquitin Isopeptidase Inhibitor I, G5 | ||
| Ubiquitin Isopeptidase Inhibitor I, G5 (NSC-144303) is a broad-spectrum cell-permeable deubiquitinating enzyme (DUB) inhibitor that affects type I IFNs and NF-κB induced by poly(I:C).*The compound is unstable in solutions, freshly prepared is recommended | ||
| M6076 | Miquelianin | Metabolite/Endogenous Metabolite |
| Quercetin 3-O-glucuronide; Quercetin 3-glucuronide | ||
| Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. | ||
| M6700 | Eeyarestatin I | Others |
| Eeyarestatin-I | ||
| Eeyarestatin I is a potent endoplasmic reticulum-associated protein degradation (ERAD) and translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. | ||
| M8421 | BC-1258 | Others |
| BC-1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. | ||
| M8496 | NSC687852 | Others |
| NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-assoc |
||
| M8678 | FG-2216 (BIQ) | HIF |
| YM-311 | ||
| BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD) with IC50 of 3.9 uM for PDH2 enzyme. | ||
| M8946 | IQ-1S | JNK |
| IQ-1 | ||
| IQ-1S is a potent and selective JNK inhibitor with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively. | ||
| M9577 | RA190 hydrochloride | Proteasome |
| RA190 HCl | ||
| RA190 HCl is a potent RPN13 and ADRM1 Inhibitor, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. | ||
| M10423 | DT2216 | PROTAC |
| DT-2216 | ||
| DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. | ||
| M10957 | MK-0429 | Integrin |
| L-000845704 | ||
| MK-0429 (L-000845704) is an oral, highly effective, selective, non-peptide integrin ubiquitous antagonist for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1 IC5 0 The values are 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM, and 12.2 nM, respectively. | ||
| M11278 | GNA002 | Histone Methyltransferase |
| GNA002 is a potent, selective, covalent EZH2 inhibitor with an IC50 of 1.1 μM against EZH2. GNA002 can specifically and covalently bind Cys668 in the EZH2-SET domain to induce EZH2 degradation through COOH terminal of ubiquitination mediated by Hsp70 interacting protein (CHIP). GNA002 effectively reduced EZH2-mediated H3K27 trimethylation and reactivated tumor suppressor genes silenced by Polycomb repressor complex 2 (PRC2). | ||
| M13436 | SJB3-019A | Deubiquitinase |
| SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM. | ||
| M14128 | Imiquimod hydrochloride | TLR |
| R 837 hydrochloride | ||
| Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. | ||
| M14325 | BI8622 | E1/E2/E3 Enzyme |
| BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM. | ||
| M14331 | TZ9 | E1/E2/E3 Enzyme |
| TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. | ||
| M14603 | Indole-3-carbinol | NF-κB |
| I3C; 3-Indolemethanol | ||
| Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). | ||
| M14866 | E3 ligase Ligand 8 | Ligand for E3 Ligase |
| E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. | ||
| M20706 | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | ||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
