About 31 results found for searched term "IQ-3" (0.105 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M11008 | IQ-3 | JNK |
| IQ-3 is a specific inhibitor of the c-JNK family and is more selective for JNK3. IQ-3 for JNK1, JNK2, and JNK3 Kd The values are 0.24 μM, 0.29 μM, and 0.066 μM, respectively. | ||
| M27956 | EPI-743 | Mitochondrial Related |
| α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075 | ||
| EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. | ||
| M1641 | Quizartinib (AC220) | FLT3 |
| AC220 | ||
| Quizartinib (AC220) is a uniquely potent and selective FLT3 inhibitor. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2227 | Imiquimod | Animal Modeling |
| Aldara, R 837; IMQ | ||
| Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity. | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M3052 | TCID | Deubiquitinase |
| 4,5,6,7-Tetrachloroindan-1,3-dione | ||
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M11227 | FM-479 | JAK |
| Fm-479 was a negative control of FM-381 and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. | ||
| M4008 | Liquiritigenin | Estrogen Receptor |
| 4',7-Dihydroxyflavanone | ||
| Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc. | ||
| M4010 | Isoliquiritigenin | Aldose Reductase |
| GU17; ISL; Isoliquiritigen | ||
| Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. | ||
| M4710 | Shionone | NLR |
| Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. | ||
| M5196 | Spautin-1 | Autophagy |
| Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. | ||
| M5298 | NSC-144303 | Apoptosis |
| Ubiquitin Isopeptidase Inhibitor I, G5 | ||
| Ubiquitin Isopeptidase Inhibitor I, G5 (NSC-144303) is a broad-spectrum cell-permeable deubiquitinating enzyme (DUB) inhibitor that affects type I IFNs and NF-κB induced by poly(I:C).*The compound is unstable in solutions, freshly prepared is recommended | ||
| M6076 | Miquelianin | Metabolite/Endogenous Metabolite |
| Quercetin 3-O-glucuronide; Quercetin 3-glucuronide | ||
| Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. | ||
| M6700 | Eeyarestatin I | Others |
| Eeyarestatin-I | ||
| Eeyarestatin I is a potent endoplasmic reticulum-associated protein degradation (ERAD) and translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. | ||
| M6766 | GS143 | IκB/IKK |
| GS-143 | ||
| GS143 is a β-TrCP1 ligase inhibitor. GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. | ||
| M6788 | HBX 41108 | Deubiquitinase |
| HBX41108 | ||
| HBX 41108 is a selective USP7 inhibitor with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. | ||
| M8421 | BC-1258 | Others |
| BC-1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. | ||
| M8496 | NSC687852 | Others |
| NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-assoc |
||
| M8678 | FG-2216 (BIQ) | HIF |
| YM-311 | ||
| BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD) with IC50 of 3.9 uM for PDH2 enzyme. | ||
| M8946 | IQ-1S | JNK |
| IQ-1 | ||
| IQ-1S is a potent and selective JNK inhibitor with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively. | ||
| M9577 | RA190 hydrochloride | Proteasome |
| RA190 HCl | ||
| RA190 HCl is a potent RPN13 and ADRM1 Inhibitor, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. | ||
| M9785 | ML364 | Deubiquitinase |
| ML-364 | ||
| ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP. | ||
| M9871 | GSK2643943A | Deubiquitinase |
| GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC). | ||
| M10423 | DT2216 | PROTAC |
| DT-2216 | ||
| DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. | ||
| M10957 | MK-0429 | Integrin |
| L-000845704 | ||
| MK-0429 (L-000845704) is an oral, highly effective, selective, non-peptide integrin ubiquitous antagonist for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1 IC5 0 The values are 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM, and 12.2 nM, respectively. | ||
| M11278 | GNA002 | Histone Methyltransferase |
| GNA002 is a potent, selective, covalent EZH2 inhibitor with an IC50 of 1.1 μM against EZH2. GNA002 can specifically and covalently bind Cys668 in the EZH2-SET domain to induce EZH2 degradation through COOH terminal of ubiquitination mediated by Hsp70 interacting protein (CHIP). GNA002 effectively reduced EZH2-mediated H3K27 trimethylation and reactivated tumor suppressor genes silenced by Polycomb repressor complex 2 (PRC2). | ||
| M13436 | SJB3-019A | Deubiquitinase |
| SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM. | ||
| M14128 | Imiquimod hydrochloride | TLR |
| R 837 hydrochloride | ||
| Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. | ||
| M14325 | BI8622 | E1/E2/E3 Enzyme |
| BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM. | ||
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