Free shipping on all orders over $ 500

BC-1258

Cat. No. M8421
BC-1258 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

BC-1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.

Chemical Information
Molecular Weight 406.57
Formula C22H22N4S2
CAS Number 1507370-40-2
Solubility (25°C) DMSO: 10 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] B B Chen, et al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis

Related Products
Benproperine phosphate

Benproperine phosphate is an orally active, potent inhibitor of actin-associated protein 2/3 complex subunit 2 (ARPC2) that attenuates the rate of actin polymerization by impairing the function of Arp2/3.Benproperine phosphate inhibits cancer cell migration and tumor metastasis and has been used in studies related to cough. Benproperine phosphate inhibits cancer cell migration and tumor metastasis and can be used in cough-related studies.

Zilebesiran

Zilebesiran is a small interfering RNA covalently linked to the N-acetylgalactosamine ligand that binds with high affinity to the hepatic asialoglycoprotein receptor.Zilebesiran specifically reduces hepatic angiotensinogen messenger RNA, thereby decreasing angiotensinogen synthesis.

Anselamimab

Anselamimab is a human IgG1κ anti-amyloidogenic fibrillar antibody targeting serum amyloid A1 (SAA1) for studies related to AL-type amyloidosis.

AZD3152

AZD3152 is a monoclonal antibody targeting SARS-CoV-2.

M9140

M9140 is an antibody drug coupling (ADC) that targets cancer cells expressing carcinoembryonic antigen-associated cell adhesion molecule 5 (CEACAM5).The cytotoxic payload in M9140 is a topoisomerase 1 (TOP1) inhibitor that prevents DNA repair.

  Catalog
Abmole Inhibitor Catalog




Keywords: BC-1258 supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.