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Shionone

Cat. No. M4710
Shionone Structure
Size Price Availability Quantity
20mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure.

Chemical Information
Molecular Weight 426.72
Formula C30H50O
CAS Number 10376-48-4
Form Solid
Solubility (25°C) Ethanol 3 mg/mL (ultrasonic and warming)
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Biao Zhang, et al. Shionone Attenuates Sepsis-Induced Acute Kidney Injury by Regulating Macrophage Polarization via the ECM1/STAT5 Pathway

[2] Xin Wang, et al. Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury

[3] Nana Xu, et al. Shionone suppresses the growth, migration and invasion of human breast cancer cells via induction of apoptosis and inhibition of MEK/ERK and STAT3 signalling pathways

[4] De-Feng Yin, et al. Development and validation of an LC/MS/MS method for simultaneous determination of shionone and epi-friedelinol in rat plasma for pharmacokinetic study after oral administration of Aster tataricus extract

[5] Satoru Sawai, et al. Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus

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