About 13 results found for searched term "NLR" (0.055 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M20412 | NLRP3 Inflammasome Inhibitor I | Immunology/Inflammation |
| NLRP3-IN-2 | ||
| NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome. | ||
| M42016 | NLRP3-IN-17 | NLR |
| NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. | ||
| M42022 | NLRP3-IN-19 | NLR |
| NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. | ||
| M42023 | NLRP3-IN-19 sodium | NLR |
| NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. | ||
| M42025 | NLRP3-IN-18 | NLR |
| NLRP3-IN-18 is a potent NLRP3 inhibitor with an IC50 value of ≤1.0 µM. | ||
| M42027 | NLRP3-IN-9 | NLR |
| NLRP3-IN-9 is a potent NLRP3 inhibitor. | ||
| M45372 | NLRP3/AIM2-IN-3 | NLR |
| NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with an IC50 of 0.077 ± 0.008 μM. | ||
| M45373 | NLRP3/AIM2-IN-2 | NLR |
| NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM. | ||
| M54569 | NLRP3 agonist 1 | NLR |
| NLRP3 agonist 1 is a potent and orally active NLRP3 agonist that activates the enzyme Caspase-1 and cleaves pro-IL-1β and pro-IL-18 pro-inflammatory cytokines into their mature forms. | ||
| M54570 | NLRP3-IN-13 | NLR |
| NLRP3-IN-13 is a potent and selective NLRP3 inhibitor that inhibits NLRP3 and NLRC4 inflammasomes and inhibits NLRP3-mediated IL-1β production with an IC50 value of 2.1 μM. In addition, NLRP3-IN-13 inhibits NLRP3 ATPase activity.NLRP3-IN-13 may be used in the study of neuroinflammation and inflammatory diseases. NLRP3-IN-13 can be used in the study of neuroinflammatory diseases. | ||
| M54571 | NLRP3-IN-10 | NLR |
| NLRP3-IN-10 is a potent NLRP3 inhibitor with an IC50 of 251.1 nM for inhibition of IL-1β. NLRP3-IN-10 attenuates the formation of ASC speckles and inhibits the activation of NLRP3 inflammatory vesicles. | ||
| M54572 | NLRP3-IN-11 | NLR |
| NLRP3-IN-11 is a NLRP3 protein inhibitor that is biologically active with an IC50 value of <0.3 μM.NLRP3-IN-11 can be used in studies related to inflammatory and degenerative diseases. | ||
| M54573 | NLRP3-IN-NBC6 | NLR |
| NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. | ||
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