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NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with an IC50 of 0.077 ± 0.008 μM.
| Molecular Weight | 266.29 |
| Formula | C16H14N2O2 |
| CAS Number | 1787787-60-3 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL Methanol 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Chunyuan Zhao, et al. Front Immunol. NLRP3 Inflammasome-A Key Player in Antiviral Responses
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