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Oridonin

Cat. No. M4578
Oridonin Structure
Synonym:

Isodonol;NSC-250682

Size Price Availability Quantity
10mg USD 53  USD53 In stock
50mg USD 105  USD105 In stock
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Quality Control & Documentation
Biological Activity

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. 

Oridonin (10 or 20 μM) causes G2/M phase cell cycle arrest in KYSE70, KYSE410 and KYSE450 cells, and induces apoptosis in these three cell lines at 20 μM. In addition, Oridonin (5, 10 or 20 μM) in combination with cisplatin or 5-FU enhances the inhibition of esophageal squamous cell carcinoma (ESCC) cell growth.

Chemical Information
Molecular Weight 364.44
Formula C20H28O6
CAS Number 28957-04-2
Solubility (25°C) DMSO 60 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiang Li, et al. Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

[2] Xi Liu, et al. Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

[3] Yuanyuan Zhang, et al. Solubility and Bioavailability Enhancement of Oridonin: A Review

[4] Huahong Yang, et al. Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways

[5] Hongbin He, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

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  Catalog
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Keywords: Oridonin, Isodonol;NSC-250682 supplier, NLR, inhibitors, activators


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