All AbMole products are for research use only, cannot be used for human consumption.
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively.
Oridonin (10 or 20 μM) causes G2/M phase cell cycle arrest in KYSE70, KYSE410 and KYSE450 cells, and induces apoptosis in these three cell lines at 20 μM. In addition, Oridonin (5, 10 or 20 μM) in combination with cisplatin or 5-FU enhances the inhibition of esophageal squamous cell carcinoma (ESCC) cell growth.
| Molecular Weight | 364.44 |
| Formula | C20H28O6 |
| CAS Number | 28957-04-2 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 4°C, dry, sealed |
[1] Xiang Li, et al. Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity
[3] Yuanyuan Zhang, et al. Solubility and Bioavailability Enhancement of Oridonin: A Review
[5] Hongbin He, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
| Related NLR Products |
|---|
| SLC3037
SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| FK 565
FK 565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| NBC19
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. |
| NT-0249
NT-0249 is an orally active NLRP3 inhibitor. |
| BAL-0028
BAL-0028 is a NLRP3 activation inhibitor with a IC50 value of 25 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
