|M10629||Troxerutin||Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.|
|M10136||GSK717||GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor.|
|M9516||INF39||INF39 is a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages.|
|M9376||Dapansutrile (OLT1177)||Dapansutrile (OLT1177) is a first-in-class potent, selective and orally active inhibitor of NLRP3 inflammasome.|
|M9263||CY-09||CY-09 is a selective and direct NLRP3 inhibitor.|
|M8083||MCC950 sodium salt (CP-456773)||MCC950 (CP-456773) sodium salt was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome.|
|M7547||NOD-IN-1||NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.|
|M6164||MCC950||MCC950 is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.|
|M5301||Cardamonin||Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.|
|M4578||Oridonin||Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.|
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