| Cat.No. | Name | Information |
|---|---|---|
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M54582 | Selnoflast | Selnoflast is an orally effective inhibitor of NLRP3 for studies related to systemic inflammation. |
| M54577 | Antcin A | Antcin A is an NLRP3 inhibitor that inhibits the assembly and activation of NLRP3 inflammatory vesicles. In addition, Antcin A inhibits pyroptosis of Kupffer cells and has hepatoprotective activity.Antcin A can be used in inflammation-related studies. |
| M54574 | Emlenoflast | Emlenoflast is a sulfonylurea compound that is also a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast can be used in studies related to inflammatory diseases. |
| M54572 | NLRP3-IN-11 | NLRP3-IN-11 is a NLRP3 protein inhibitor that is biologically active with an IC50 value of <0.3 μM.NLRP3-IN-11 can be used in studies related to inflammatory and degenerative diseases. |
| M54571 | NLRP3-IN-10 | NLRP3-IN-10 is a potent NLRP3 inhibitor with an IC50 of 251.1 nM for inhibition of IL-1β. NLRP3-IN-10 attenuates the formation of ASC speckles and inhibits the activation of NLRP3 inflammatory vesicles. |
| M45373 | NLRP3/AIM2-IN-2 | NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM. |
| M45372 | NLRP3/AIM2-IN-3 | NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with an IC50 of 0.077 ± 0.008 μM. |
| M45116 | NX-13 | NX-13 is a novel oral small molecule NLRX1 agonist, which can increase oxidative phosphorylation in immune cells, decrease the differentiation of effector CD4+ T cells, and reduce the production of inflammatory cytokines in the gastrointestinal tract through activation of the NLRX1 pathway, and can be used in studies related to ulcerative colitis (UC). |
| M45061 | NT-0796 | NT-0796 is an isopropyl ester that is converted intracellularly to NDT-197959 and is also a selective, CNS-transmitting NLRP3 inhibitor with an IC50 of 0.32 nM in PBMC.May be used in studies related to neuroinflammatory diseases. |
| M20827 | BMS-986299 | BMS-986299 is a first-in-class (first-in-class) NLRP3 inflammatory vesicle agonist that induces IL8 release to activate natural killer (NK) cells with an EC50 of 1.28 μM. |
| M14102 | Cardamonin | Cardamonin (Cardamomin) acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M13338 | Trimethylamine N-oxide | Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway. |
| M10838 | JC124 | JC124 IS A SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME. JC124 HAS ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS. |
| M10687 | YQ128 | YQ128 is a potent, selective second-generation NLRP3 inflammatory body inhibitor,IC50 0.30 μM. YQ128 significantly and selectively inhibits the production of IL-1β, but does not inhibit the production of TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity. |
| M10685 | Arglabin | Arglabin ((+)-Arglabin, a natural product isolated from Artemisia annua, is an inhibitor of the NLRP3 inflammasome. Arglabin has anti-inflammatory and anti-tumor activity. Arglabin's antitumor activity is achieved by inhibiting farnesyl metastase and activating the RAS proto-oncogene. |
| M10629 | Troxerutin | Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation. |
| M10583 | RRX-001 | Rrx-001 is a hypoxic selective epigenetic factor that has been used as a radiation or chemotherapy sensitizer to induce apoptosis. Rrx-001 is an immune checkpoint inhibitor that down-regulates CD47 and SIRP-α. Rrx-001 is also an effective inhibitor of G6PD with strong antimalarial activity. Rrx-001 inhibits the expression of CD47 in tumor cells by inhibiting c-myC, a positive regulator of CD47. |
| M10136 | GSK717 | GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. |
| M9516 | INF39 | INF39 is a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. *The compound is unstable in solutions, freshly prepared is recommended |
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