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YQ128 is a potent, selective second-generation NLRP3 inflammatory body inhibitor,IC50 0.30 μM. YQ128 significantly and selectively inhibits the production of IL-1β, but does not inhibit the production of TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity.
| Molecular Weight | 545.11 |
| Formula | C27H29ClN2O4S2 |
| CAS Number | 2454246-18-3 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NLR Products |
|---|
| SLC3037
SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| FK 565
FK 565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| NBC19
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. |
| NT-0249
NT-0249 is an orally active NLRP3 inhibitor. |
| BAL-0028
BAL-0028 is a NLRP3 activation inhibitor with a IC50 value of 25 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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