| Cat.No. | Name | Information |
|---|---|---|
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M4710 | Shionone | Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
| M4578 | Oridonin | Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| M4518 | Procyanidin-B2 | Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| M4130 | Ruscogenin | Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| M2857 | Nodinitib-1 | Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| M54579 | (±)11(12)-EET | (±)11(12)-EET is an NLRP3 inflammatory vesicle inhibitor that can be used in studies related to anti-inflammation, neovascularization, and cardioprotection. |
| M54576 | ADS032 | ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation and reduces NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduces NLRP3-induced ASC speck formation. In addition, ADS032 protects mice from the deadly influenza A virus, reduces lung inflammation and improves survival. |
| M54575 | Emlenoflast sodium | Emlenoflast sodium is a sulfonylurea and a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast sodium can be used in the study of inflammatory diseases. |
| M54573 | NLRP3-IN-NBC6 | NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. |
| M54570 | NLRP3-IN-13 | NLRP3-IN-13 is a potent and selective NLRP3 inhibitor that inhibits NLRP3 and NLRC4 inflammasomes and inhibits NLRP3-mediated IL-1β production with an IC50 value of 2.1 μM. In addition, NLRP3-IN-13 inhibits NLRP3 ATPase activity.NLRP3-IN-13 may be used in the study of neuroinflammation and inflammatory diseases. NLRP3-IN-13 can be used in the study of neuroinflammatory diseases. |
| M54569 | NLRP3 agonist 1 | NLRP3 agonist 1 is a potent and orally active NLRP3 agonist that activates the enzyme Caspase-1 and cleaves pro-IL-1β and pro-IL-18 pro-inflammatory cytokines into their mature forms. |
| M54568 | VENT-02 | VENT-02 is a brain-permeable NLRP3 inhibitor for studies related to neurological disorders. |
| M54567 | VENT-01 | VENT-01 is an NLRP3 inhibitor for studies related to non-alcoholic steatohepatitis (NASH) and chronic kidney disease. |
| M54538 | NT-0249 | NT-0249 is an NLRP3 inhibitor that can be used in studies related to inflammation. |
| M45277 | VTX-2735 | VTX-2735 is an NLRP3 inhibitor that can be used in studies related to inflammatory diseases. |
| M45276 | Somalix | Somalix is an orally active, peripherally restricted NLRP3 inhibitor for studies related to arthritis and inflammatory diseases. |
| M45275 | IFM-2427 | IFM-2427 is an NLRP3 inhibitor that can be used in studies related to non-alcoholic steatohepatitis (NASH) and gout. |
| M45116 | NX-13 | NX-13 is a novel oral small molecule NLRX1 agonist, which can increase oxidative phosphorylation in immune cells, decrease the differentiation of effector CD4+ T cells, and reduce the production of inflammatory cytokines in the gastrointestinal tract through activation of the NLRX1 pathway, and can be used in studies related to ulcerative colitis (UC). |
| M45061 | NT-0796 | NT-0796 is an isopropyl ester that is converted intracellularly to NDT-197959 and is also a selective, CNS-transmitting NLRP3 inhibitor with an IC50 of 0.32 nM in PBMC.May be used in studies related to neuroinflammatory diseases. |
| M42028 | iE-DAP | iE-DAP is a biological active peptide. |
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