| Cat.No. | Name | Information |
|---|---|---|
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M9082 | ISO-1 | ISO-1, also known as MIF Antagonist, is a MIF inhibitor with an IC50 of 7 uM. ISO-1 exerts anti-cancer effects on PANC-1 cell proliferation, migration and invasion in vitro, and inhibited PANC-1 cell-induced tumour growth in xenograft mice in vivo. |
| M7547 | NOD-IN-1 | NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively. |
| M4710 | Shionone | Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
| M4578 | Oridonin | Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| M4518 | Procyanidin-B2 | Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| M4130 | Ruscogenin | Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| M2857 | Nodinitib-1 | Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| M58473 | SLC3037 | SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| M58195 | FK 565 | FK 565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| M56385 | NBC19 | NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. |
| M56384 | NT-0249 | NT-0249 is an orally active NLRP3 inhibitor. |
| M56383 | BAL-0028 | BAL-0028 is a NLRP3 activation inhibitor with a IC50 value of 25 nM. |
| M56382 | NLRP3 antagonist 2 | NLRP3 antagonist 2 (comopound 102) is a NLRP3 antagonist. |
| M54579 | (±)11(12)-EET | (±)11(12)-EET is an NLRP3 inflammatory vesicle inhibitor that can be used in studies related to anti-inflammation, neovascularization, and cardioprotection. |
| M54576 | ADS032 | ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation and reduces NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduces NLRP3-induced ASC speck formation. In addition, ADS032 protects mice from the deadly influenza A virus, reduces lung inflammation and improves survival. |
| M54575 | Emlenoflast sodium | Emlenoflast sodium is a sulfonylurea and a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast sodium can be used in the study of inflammatory diseases. |
| M54573 | NLRP3-IN-NBC6 | NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. |
| M54570 | NLRP3-IN-13 | NLRP3-IN-13 is a potent and selective NLRP3 inhibitor that inhibits NLRP3 and NLRC4 inflammasomes and inhibits NLRP3-mediated IL-1β production with an IC50 value of 2.1 μM. In addition, NLRP3-IN-13 inhibits NLRP3 ATPase activity.NLRP3-IN-13 may be used in the study of neuroinflammation and inflammatory diseases. NLRP3-IN-13 can be used in the study of neuroinflammatory diseases. |
| M54569 | NLRP3 agonist 1 | NLRP3 agonist 1 is a potent and orally active NLRP3 agonist that activates the enzyme Caspase-1 and cleaves pro-IL-1β and pro-IL-18 pro-inflammatory cytokines into their mature forms. |
| M54568 | VENT-02 | VENT-02 is a brain-permeable NLRP3 inhibitor for studies related to neurological disorders. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
