| Cat.No. | Name | Information |
|---|---|---|
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M42027 | NLRP3-IN-9 | NLRP3-IN-9 is a potent NLRP3 inhibitor. |
| M42026 | JT002 | JT002 is an orally active inhibitor of the NLRP3 inflammasome. |
| M42025 | NLRP3-IN-18 | NLRP3-IN-18 is a potent NLRP3 inhibitor with an IC50 value of ≤1.0 µM. |
| M42024 | TriDAP | TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a biological active peptide. |
| M42023 | NLRP3-IN-19 sodium | NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. |
| M42022 | NLRP3-IN-19 | NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. |
| M42021 | INF200 | INF200 is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. |
| M42020 | Selnoflast calcium | Selnoflast calcium is a NLRP3 inhibitor (extracted from patent WO2019008025). |
| M42019 | Usnoflast | Usnoflast is a NLRP3 modulator, as well as a non-steroidal anti-inflammatory agent (NSAD). |
| M42018 | Selnoflast potassium | Selnoflast (potassium) is a NLRP3 inhibitor (extracted from patent WO2019008025). |
| M42017 | M-TriDAP | M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a biological active peptide. |
| M42016 | NLRP3-IN-17 | NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. |
| M30978 | Fc 11a-2 | Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS)-induced murine experimental colitis. |
| M30795 | INF4E | INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction. |
| M21531 | GDC-2394 | GDC-2394 is an oral inhibitor of NLRP3 inflammasome. The NLRP3 inflamome, the best studied and most characterized, also inhibits IL-1β with IC50 of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). |
| M17240 | Methyl gallate | Methyl gallate is a polyphenol commonly found in the plant kingdom and is also an inhibitor of NLRP3, inhibiting the activation of NLRP3 inflammatory vesicles. In vitro, Methyl gallate is also a potent, highly specific inhibitor of herpes simplex virus (HSV) and has the ability to inhibit Treg cell migration. |
| M10839 | JC-171 | JC-171 is a selective inhibitor of NLRP3 inflammasomes that inhibits the release of IL-1β by macrophages induced by LPS/ATP IC50 The value is 8.45 μM. |
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