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NOD-IN-1

Cat. No. M7547
NOD-IN-1 Structure
Synonym:

NOD2-

Size Price Availability Quantity
1mg USD 97  USD97 In stock
5mg USD 195  USD195 In stock
10mg USD 310  USD310 In stock
25mg USD 620  USD620 In stock
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Quality Control
Biological Activity

NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 343.4
Formula C18H17NO4S
CAS Number 132819-92-2
Purity 99.69%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C
References

[1] Soo Jeong Park, et al. Proc Natl Acad Sci U S A. Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns

[2] Beversdorf LJ, et al. Toxins (Basel). Variable Cyanobacterial Toxin and Metabolite Profiles across Six Eutrophic Lakes of Differing Physiochemical Characteristics.

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Keywords: NOD-IN-1, NOD2- supplier, NLR, inhibitors

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