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Arglabin ((+)-Arglabin, a natural product isolated from Artemisia annua, is an inhibitor of the NLRP3 inflammasome. Arglabin has anti-inflammatory and anti-tumor activity. Arglabin's antitumor activity is achieved by inhibiting farnesyl metastase and activating the RAS proto-oncogene.
| Molecular Weight | 246.30 |
| Formula | C15H18O3 |
| CAS Number | 84692-91-1 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Tracey L Freeman, et al. Front Immunol. Targeting the NLRP3 Inflammasome in Severe COVID-19
[5] Shabir H Lone, et al. Chem Biol Interact. Arglabin: From isolation to antitumor evaluation
| Related NLR Products |
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SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| FK 565
FK 565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| NBC19
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. |
| NT-0249
NT-0249 is an orally active NLRP3 inhibitor. |
| BAL-0028
BAL-0028 is a NLRP3 activation inhibitor with a IC50 value of 25 nM. |
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