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NLRP3/AIM2-IN-2

Cat. No. M45373

All AbMole products are for research use only, cannot be used for human consumption.

NLRP3/AIM2-IN-2 Structure
Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 90  USD90 In stock
25mg USD 175  USD175 In stock
50mg USD 270  USD270 In stock
100mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM.

Chemical Information
Molecular Weight 257.28
Formula C15H15NO3
CAS Number 791840-86-3
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jianing Fu, et al. Annu Rev Immunol. Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation

[2] Cong-Yuan Xia, et al. Pharmacol Res. The NLRP3 inflammasome in depression: Potential mechanisms and therapies

[3] Chunyuan Zhao, et al. Front Immunol. NLRP3 Inflammasome-A Key Player in Antiviral Responses

[4] Qinyu Wang, et al. Br J Pharmacol. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

[5] Matthew S J Mangan, et al. Nat Rev Drug Discov. Targeting the NLRP3 inflammasome in inflammatory diseases

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  Catalog
Abmole Inhibitor Catalog




Keywords: NLRP3/AIM2-IN-2 supplier, NLR, inhibitors, activators

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