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JC124

Cat. No. M10838
JC124  Structure
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

JC124 IS A SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME. JC124 HAS ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 382.86
Formula C17H19ClN2O4S
CAS Number 1638611-48-9
Purity >97%
Solubility DMSO ≥ 200 mg/mL
Storage at -20°C
References

[1] Ning Li, et al. Pharmacol Res. Pathway network of pyroptosis and its potential inhibitors in acute kidney injury

[2] Henry S Sacks. Ann Intern Med. The Novavax vaccine had 90% efficacy against COVID-19 ≥7 d after the second dose

[3] Ram Kuwar, et al. J Alzheimers Dis. A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice

[4] Ram Kuwar, et al. J Neuroinflammation. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

[5] Jacob Fulp, et al. J Med Chem. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

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Keywords: JC124 supplier, NLR, inhibitors

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