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Trimethylamine N-oxide

Cat. No. M13338
Trimethylamine N-oxide Structure
Size Price Availability Quantity
1g USD 70  USD70 In stock
5g USD 205  USD205 In stock
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Quality Control & Documentation
Biological Activity

Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.

Chemical Information
Molecular Weight 75.11
Formula C3H9NO
CAS Number 1184-78-7
Solubility (25°C) Water 90 mg/mL
DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Siyu He, et al. Cardiovasc Toxicol. Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases

[2] Kunpeng Wu, et al. Blood. The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

[3] Yingqian Zhu, et al. APMIS. Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide

[4] Sifan Chen, et al. Cell Metab. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

[5] Steven H Zeisel, et al. Annu Rev Nutr. Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease

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Keywords: Trimethylamine N-oxide supplier, NLR, inhibitors, activators


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