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NLRP3 Inflammasome Inhibitor I

Cat. No. M20412

All AbMole products are for research use only, cannot be used for human consumption.

NLRP3 Inflammasome Inhibitor I Structure
Synonym:

NLRP3-IN-2

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 65  USD65 In stock
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Quality Control & Documentation
Biological Activity

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

Chemical Information
Molecular Weight 368.84
Formula C16H17ClN2O4S
CAS Number 16673-34-0
Solubility (25°C) DMSO 73 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alexander Hooftman, et al. Cell Metab. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

[2] Ayesha Zahid, et al. Front Immunol. Pharmacological Inhibitors of the NLRP3 Inflammasome

[3] Karen V Swanson, et al. Nat Rev Immunol. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

[4] Yang Yang, et al. Cell Death Dis. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

[5] Stefano Toldo, et al. Nat Rev Cardiol. The NLRP3 inflammasome in acute myocardial infarction

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Keywords: NLRP3 Inflammasome Inhibitor I, NLRP3-IN-2 supplier, Immunology/Inflammation, inhibitors, activators

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