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Cat. No. M3052
TCID Structure
Size Price Availability
10mg USD 110  USD110 Out of stock
200mg USD 1250  USD1250 Out of stock
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Quality Control & Documentation
Biological Activity

TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

Chemical Information
Molecular Weight 283.92
Formula C9H2Cl4O2
CAS Number 30675-13-9
Form Solid
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Daniel Hochdorfer, et al. Automated, label-free TCID 50 assay to determine the infectious titer of virus-based therapeutics

[2] Patrick T Keiser, et al. Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID 50 Assays

[3] Hiroki Kitagawa, et al. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination

[4] Chengfeng Lei, et al. On the Calculation of TCID 50 for Quantitation of Virus Infectivity

[5] Martin Lock, et al. Measuring the Infectious Titer of Recombinant Adenovirus Using Tissue Culture Infection Dose 50% (TCID 50) End-Point Dilution and Quantitative Polymerase Chain Reaction (qPCR)

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Abmole Inhibitor Catalog

Keywords: TCID supplier, Deubiquitinase, inhibitors, activators

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