Free shipping on all orders over $ 500

TCID

Cat. No. M3052
TCID Structure
Size Price Availability
10mg USD 110  USD110 Out of stock
200mg USD 1250  USD1250 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

Chemical Information
Molecular Weight 283.92
Formula C9H2Cl4O2
CAS Number 30675-13-9
Form Solid
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniel Hochdorfer, et al. Automated, label-free TCID 50 assay to determine the infectious titer of virus-based therapeutics

[2] Patrick T Keiser, et al. Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID 50 Assays

[3] Hiroki Kitagawa, et al. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination

[4] Chengfeng Lei, et al. On the Calculation of TCID 50 for Quantitation of Virus Infectivity

[5] Martin Lock, et al. Measuring the Infectious Titer of Recombinant Adenovirus Using Tissue Culture Infection Dose 50% (TCID 50) End-Point Dilution and Quantitative Polymerase Chain Reaction (qPCR)

Related Deubiquitinase Products
TNG348

TNG348 is a novel, oral, potent and selective ubiquitin-specific protease 1 (USP1) inhibitor for studies related to BRCA1/2 mutations and other homologous recombination defect (HRD)+ cancers.

FT-3171

FT-3171 is a small molecule ubiquitin-specific protease 1 (USP1) inhibitor targeting a novel DNA damage repair (DDR) pathway for studies related to solid tumors.

BAY-728

BAY-728 serves as a negative control for BAY-805, a potent and selective USP21 inhibitor.

BAY-805

BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21 with high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common off-target enzymes.

USP1-IN-6

USP1-IN-6 is a USP1 inhibitor (IC50<50 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: TCID supplier, Deubiquitinase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.