| Cat.No. | Name | Information |
|---|---|---|
| M2565 | PR-619 | PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. |
| M58161 | CMPD-39 | CMPD-39 is a selective USP30 inhibitor with an IC50 of 0.02 μM. CMPD-39 increases protein ubiquitination and accelerates mitophagy. |
| M55951 | XL177A | XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. |
| M28037 | USP7/USP47 inhibitor | USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. |
| M27876 | LCAHA | LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. |
| M25385 | Vialinin A | Vialinin A (Terrestrin A) is a potent inhibitor of ubiquitin-specific peptidases with IC50 values of 1.5, 5.9 and 22.3 μM for ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB), respectively. |
| M21141 | GNE-6640 | GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively. |
| M13631 | MF-094 | MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy. |
| M13630 | HBX 19818 | HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM. |
| M13628 | EOAI3402143 | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. |
| M13627 | DUB-IN-3 | DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. |
| M13626 | DUB-IN-2 | DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. |
| M13625 | DUB-IN-1 | DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8. |
| M13436 | SJB3-019A | SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM. |
| M13390 | C527 | C527 is an inhibitor of pan-dub enzyme with an IC50 value of 0.88 μM. |
| M10753 | VLX1570 | VLX1570 is a competitive inhibitor of proteasome deuteronase (DUBs), with IC50 of 10 μM. |
| M10752 | GNE-6776 | GNE-6776 is a potent, selective USP7 inhibitor with oral activity. |
| M10751 | USP7-IN-8 | USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in the Ub-Rho110 assay.USP7-IN-8 is inactive against USP47 and USP5.USP7-IN-8 has anticancer effects. |
| M10504 | IU1-47 | IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. |
| M9871 | GSK2643943A | GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC). |
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