| Cat.No. | Name | Information |
|---|---|---|
| M28037 | USP7/USP47 inhibitor | USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. |
| M25385 | Vialinin A | Vialinin A (Terrestrin A) is a potent inhibitor of ubiquitin-specific peptidases with IC50 values of 1.5, 5.9 and 22.3 μM for ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB), respectively. |
| M21141 | GNE-6640 | GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively. |
| M13631 | MF-094 | MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy. |
| M13630 | HBX 19818 | HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM. |
| M13628 | EOAI3402143 | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. |
| M13626 | DUB-IN-2 | DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. |
| M13625 | DUB-IN-1 | DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8. |
| M13436 | SJB3-019A | SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM. |
| M13390 | C527 | C527 is an inhibitor of pan-dub enzyme with an IC50 value of 0.88 μM. |
| M10753 | VLX1570 | VLX1570 is a competitive inhibitor of proteasome deuteronase (DUBs), with IC50 of 10 μM. |
| M10752 | GNE-6776 | GNE-6776 is a potent, selective USP7 inhibitor with oral activity. |
| M10751 | USP7-IN-8 | USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in the Ub-Rho110 assay.USP7-IN-8 is inactive against USP47 and USP5.USP7-IN-8 has anticancer effects. |
| M10504 | IU1-47 | IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. |
| M9871 | GSK2643943A | GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. |
| M9785 | ML364 | ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP. |
| M9654 | GRL0617 | GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with IC50 of 0.6 μM and Ki of 0.49 μM. |
| M9639 | SJB2-043 | Sjb2-043 inhibited USP1/UAF1 complex with IC50 of 544 nM. |
| M3052 | TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. |
| M2807 | LDN-57444 | LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
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