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Deubiquitinase Deubiquitinase

Inhibitors

Cat.No.  Name Information
M21262 FT3967385 FT3967385 is a novel USP30 inhibitor that recapitulates the genetic deletion of USP30 and triggers mitochondrial ubiquitination of PINK1-PARKIN amplification.
M21141 GNE-6640 GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively.
M13632 USP7-IN-1 USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.
M13631 MF-094 MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy.
M13630 HBX 19818 HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM.
M13629 GSK2643943A GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC50 of 160 nM for USP20/Ub-Rho.
M13628 EOAI3402143 EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.
M13627 DUB-IN-3 DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.
M13626 DUB-IN-2 DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
M13625 DUB-IN-1 DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8.
M13624 6RK73 6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer.
M13436 SJB3-019A SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM.
M13390 C527 C527 is an inhibitor of pan-dub enzyme with an IC50 value of 0.88 μM.
M10818 FT827 FT827 is a selective covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM)。 FT827 with USP7 Catalytic Domain (USP7CDresidues 208-560) combined, apparent Kd The value is 7.8 μM.
M10817 FT671 FT671 is a potent, non-covalent, selective USP7 inhibitor,IC50 The value is 52 nM, bound to the USP7 catalytic domain Kd The value is 65 nM.
M10753 VLX1570 VLX1570 is a competitive inhibitor of proteasome deuteronase (DUBs),IC50 约10 μM。
M10752 GNE-6776 GNE-6776 is a potent, selective USP7 inhibitor with oral activity.
M10751 USP7-IN-8 USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in the Ub-Rho110 assay.USP7-IN-8 is inactive against USP47 and USP5.USP7-IN-8 has anticancer effects.
M10504 IU1-47 IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM.
M9871 GSK2643943A GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM.



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