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GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively. cytotoxicity of chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
Molecular Weight | 330.38 |
Formula | C20H18N4O |
CAS Number | 2009273-67-8 |
Solubility (25°C) | DMSO : 5 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lorna Kategaya, et al. Nature. USP7 small-molecule inhibitors interfere with ubiquitin binding
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