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GNE-6640

Cat. No. M21141

All AbMole products are for research use only, cannot be used for human consumption.

GNE-6640  Structure
Size Price Availability Quantity
1mg USD 70  USD70 In stock
5mg USD 188  USD188 In stock
10mg USD 290  USD290 In stock
25mg USD 580  USD580 In stock
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Quality Control & Documentation
Biological Activity

GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively. cytotoxicity of chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.

Chemical Information
Molecular Weight 330.38
Formula C20H18N4O
CAS Number 2009273-67-8
Solubility (25°C) DMSO : 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lorna Kategaya, et al. Nature. USP7 small-molecule inhibitors interfere with ubiquitin binding

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LDN-91946 

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM.

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  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-6640 supplier, Deubiquitinase, inhibitors, activators

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