Certificate of Analysis

 

Product Name: GNE-6640
Catalog Number: M21141
CAS Number: 2009273-67-8

Physical and Chemical Properties
Formula: C20H18N4O
Molecular Weight: 330.38
Solubility: DMSO : 5 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: GNE-6640  Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.