About 14 results found for searched term "Deubiquitinase" (0.219 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1754 | WP1130 | JAK |
| Degrasyn | ||
| Degrasyn (WP1130) is a small molecular deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. | ||
| M2431 | b-AP15 | Deubiquitinase |
| NSC 687852 | ||
| b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M8496 | NSC687852 | Others |
| NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-assoc |
||
| M9785 | ML364 | Deubiquitinase |
| ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM) with potential anticancer activity. | ||
| M13626 | DUB-IN-2 | Deubiquitinase |
| DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. | ||
| M13627 | DUB-IN-3 | Deubiquitinase |
| DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. | ||
| M13628 | EOAI3402143 | Deubiquitinase |
| EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. | ||
| M21132 | NJH-2-057 | CFTR |
| NJH-2-057 is a conjugate of the deubiquitinase OTUB1 covalent ligand-linked lumacaftor, which stabilizes mutant CFTR proteins in cells. | ||
| M27876 | LCAHA | Deubiquitinase |
| LCA hydroxyamide | ||
| LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. | ||
| M29206 | EN523 | Others |
| EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1. | ||
| M30827 | STD1T | Deubiquitinase |
| STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay. | ||
| M30836 | STAMBP-IN-1 | Deubiquitinase |
| STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC50 value of 0.33 mM. | ||
| M41453 | GK13S | Deubiquitinase |
| G13KS is a deubiquitinase UCHL1 ligand and inhibitor. | ||
| M54656 | NJH-2-056 | Others |
| NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking EN523, a recruitment factor for OTUB1, to lumacaftor, a CFTR chaperone protein.NJH-2-056 can be used in cystic fibrosis-related studies. | ||
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