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NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitinases (DUBs) UCHL5 and USP14, with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. NSC687852 induces cell-cycle arrest and apoptosis in several colon cancers and in CNS cells, and suppresses tumor growth in various mouse models.
| Molecular Weight | 419.39 |
| Formula | C22H17N3O6 |
| CAS Number | 330450-45-8 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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