| Cat.No. | Name | Information |
|---|---|---|
| M2431 | b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M2196 | P22077 | P22077 is a selective inhibitor of ubiquitin-specific protease (USP) 7 with EC50 of 8.6 μM. |
| M2195 | P5091 | P5091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 with IC50 of 4.2 μM. |
| M50217 | TNG348 | TNG348 is a novel, oral, potent and selective ubiquitin-specific protease 1 (USP1) inhibitor for studies related to BRCA1/2 mutations and other homologous recombination defect (HRD)+ cancers. |
| M50216 | FT-3171 | FT-3171 is a small molecule ubiquitin-specific protease 1 (USP1) inhibitor targeting a novel DNA damage repair (DDR) pathway for studies related to solid tumors. |
| M49356 | BAY-728 | BAY-728 serves as a negative control for BAY-805, a potent and selective USP21 inhibitor. |
| M49355 | BAY-805 | BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21 with high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common off-target enzymes. |
| M41456 | USP1-IN-6 | USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). |
| M41455 | USP1-IN-5 | USP1-IN-5 is a USP1 inhibitor (IC50<50 nM). |
| M41454 | CT1113 | CT1113 is a potent USP28 and USP25 inhibitor. |
| M41453 | GK13S | G13KS is a deubiquitinase UCHL1 ligand and inhibitor. |
| M41452 | USP1-IN-4 | USP1-IN-4 is an effective USP1 inhibitor with an IC50 value of 2.44 nM. |
| M41451 | USP7-IN-12 | USP7-IN-12 is a potent and orally active Usp7 inhibitor with an IC50 value of 3.67 nM. |
| M41450 | IMP-1710 | IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. |
| M41449 | USP28-IN-3 | USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
| M41448 | USP28-IN-2 | USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
| M41447 | USP28-IN-4 | USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
| M40720 | I-138 | I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. |
| M30836 | STAMBP-IN-1 | STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC50 value of 0.33 mM. |
| M30827 | STD1T | STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay. |
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