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USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in the Ub-Rho110 assay.USP7-IN-8 is inactive against USP47 and USP5.USP7-IN-8 has anticancer effects.
| Molecular Weight | 347.41 |
| Formula | C21H21N3O2 |
| CAS Number | 2009273-60-1 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lorna Kategaya, et al. Nature. USP7 small-molecule inhibitors interfere with ubiquitin binding
| Related Deubiquitinase Products |
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FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. |
| XL177A
XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. |
| LDN-91946
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM. |
| USP5-IN-1
USP5-IN-1, a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. |
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