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HBX 41108 is a inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). HBX 41108 displays uncompetitive inhibition. HBX 41108 also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). HBX 41108 stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
| Molecular Weight | 266.64 |
| Formula | C13H3ClN4O |
| CAS Number | 924296-39-9 |
| Solubility (25°C) | DMSO 120 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Deubiquitinase Products |
|---|
| CMPD-39
CMPD-39 is a selective USP30 inhibitor with an IC50 of 0.02 μM. CMPD-39 increases protein ubiquitination and accelerates mitophagy. |
| FT709
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. |
| XL177A
XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. |
| LDN-91946
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM. |
| USP5-IN-1
USP5-IN-1, a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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