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Cat. No. M13436
SJB3-019A  Structure
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Biological Activity

SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM.

Chemical Information
Molecular Weight 276.25
Formula C16H8N2O3
CAS Number 2070015-29-9
Solubility (25°C) DMSO : 10 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Zhe Lu, et al. Anticancer Drugs. Ubiquitin-specific protease 1 inhibition sensitizes hepatocellular carcinoma cells to doxorubicin by ubiquitinated proliferating cell nuclear antigen-mediated attenuation of stemness

[2] Xingyi Kuang, et al. Int J Med Sci. Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells

[3] Deepika Sharma Das, et al. Clin Cancer Res. Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

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