SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM.
|Solubility (25°C)||DMSO : 10 mg/mL|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Zhe Lu, et al. Anticancer Drugs. Ubiquitin-specific protease 1 inhibition sensitizes hepatocellular carcinoma cells to doxorubicin by ubiquitinated proliferating cell nuclear antigen-mediated attenuation of stemness
 Xingyi Kuang, et al. Int J Med Sci. Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells
 Deepika Sharma Das, et al. Clin Cancer Res. Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells
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