SJB3-019A is a novel and effective inhibitor of ubiquitin specific protease 1 (USP1), which can promote ID1 degradation and cytotoxicity of K562 cells by 5 times than SJB2-043, IC50 is 0.0781 μM.
| Molecular Weight | 276.25 |
| Formula | C16H8N2O3 |
| CAS Number | 2070015-29-9 |
| Solubility (25°C) | DMSO : 10 mg/mL |
| Storage | -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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FT-3171 is a small molecule ubiquitin-specific protease 1 (USP1) inhibitor targeting a novel DNA damage repair (DDR) pathway for studies related to solid tumors. |
| BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective USP21 inhibitor. |
| BAY-805
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| USP1-IN-6
USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). |
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