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Cat. No. M11008
IQ-3  Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 135  USD135 In stock
25mg USD 270  USD270 In stock
50mg USD 420  USD420 In stock
100mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

IQ-3 is a specific inhibitor of the c-JNK family and is more selective for JNK3. IQ-3 for JNK1, JNK2, and JNK3 Kd The values are 0.24 μM, 0.29 μM, and 0.066 μM, respectively.

Chemical Information
Molecular Weight 341.32
Formula C20H11N3O3
CAS Number 312538-03-7
Solubility (25°C) DMSO ≥ 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Paul H Frankel, et al. JAMA Netw Open. Model of a Queuing Approach for Patient Accrual in Phase 1 Oncology Studies

[2] Katya De Groote, et al. J Cardiol. Increased aortic stiffness in prepubertal girls with Turner syndrome

[3] Deok-Jin Jang, et al. Mol Cells. Characterization of novel calmodulin binding domains within IQ motifs of IQGAP1

[4] G David Batty, et al. Eur J Cardiovasc Prev Rehabil. Does IQ predict cardiovascular disease mortality as strongly as established risk factors? Comparison of effect estimates using the West of Scotland Twenty-07 cohort study

[5] Vijaya M Lakshmi, et al. Chem Res Toxicol. 2-Nitrosoamino-3-methylimidazo[4,5-f]quinoline stability and reactivity

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Abmole Inhibitor Catalog

Keywords: IQ-3 supplier, JNK, inhibitors, activators

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