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 About 30 results found for searched term "JNK" (0.019 seconds)

Cat.No.  Name Information
M2013 JNK-IN-8 JNK-IN-8 is a selective JNK inhibitor that inhibits phosphorylation of c-Jun.
M2076 SP600125 SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM.
M2506 CGP 57380 CGP 57380 is potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.
M2745 GW5074 GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted.
M2785 JNK Inhibitor IX (SC202671) JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.
M2927 PF-04880594 PF-04880594 is a RAF inhibitor for BRAF/BRAFV599E and c-RAF with IC50 of 0.19 nM/0.13 nM and 0.39 nM, >100-fold selectivity over CSNK1, JNK2/3 and p38.
M3048 TAK-715 TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
M4074 Ginsenoside-Re Ginsenoside Re (Ginsenoside B2) is a ginseng - ginseng extract. Ginsenoside Re reduces beta-amyloid (Aβ). Ginsenoside Re also exerts anti-inflammatory effects by inhibiting JNK and NF-κB.
M4361 Polyphyllin-I Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.
M4415 Sesamolin Sesaminol can be isolated from Justicia Orbiculata and has antioxidant activity. Sesaminol inhibits lipid peroxidation and has neuroprotective effect. Sesaminol inhibits MAPK cascade by inhibiting phosphorylation of JNK, P38 MAPKs, and Caspase-3.
M4676 LOUREIRIN-B Loureirin B is a flavonoid isolated from The blood tree of Pterygophyllum SPP. It is an inhibitor of PAI-1 with IC50 value of 26.10 μM. Loureirin B can inhibit the phosphorylation of KATP, ERK and JNK at the same time, showing an anti-diabetes effect.
M4746 Isovitexin Isovitexin, a flavonoid obtained from Asian rice seeds, has antioxidant and anti-inflammatory activities. Isovitexin acts like an inhibitor of JNK1/2 and inhibits NF-κB activation.
M5145 Anisomycin Anisomycin is a pyrrolidine antibiotic, which inhibits protein synthesis, and also act as a JNK activator.
M6408 AEG 3482 AEG 3482 is a inhibitor of JNK signaling.
M6503 BI 78D3 BI 78D3 is a selective, competitive JNK inhibitor.
M7329 SR 3576 SR 3576 is a highly potent and selective JNK3 inhibitor.
M7395 TCS JNK 6o TCS JNK 6o is a selective JNK inhibitor.
M7582 SB 239063 SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.
M8365 BI-87G3 BI-87G3 is a cell-permeable, potent and selective competitive inhibitor of the c-Jun N-terminal kinase (JNK).
M8391 Icaritin Icaritin (Anhydroicaritin) is a flavonoid derivative of isoprene from Epimedium Genusis. It effectively inhibited the proliferation of K562 cells (IC50 8 µM) and primary CML cells (IC50 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3/AKT signaling and enhance osteogenesis.
M8921 Bentamapimod Bentamapimod, also known as AS602801, is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.
M8946 IQ-1S IQ-1S is a potent and selective JNK inhibitor with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
M9388 Tanzisertib Tanzisertib (CC-930) is a potent JNK1/2/3 inhibitor with IC50s of 61/7/6 nM, respectively.
M9718 DB07268 DB07268 is is a potent and selective JNK1 inhibitor, with IC50 of 9 nM.
M10257 Glycycoumarin Glycycoumarin is a bioactive coumarin of licorice, it inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway.
M10289 Cucurbitacin D Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
M10365 L-JNKI-1 L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.
M10633 AS601245 AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50 values of 150, 220, and 70 nM for JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively.
M10710 L-Quebrachitol L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
M11008 IQ-3 IQ-3 is a specific inhibitor of the c-JNK family and is more selective for JNK3. IQ-3 for JNK1, JNK2, and JNK3 Kd The values are 0.24 μM, 0.29 μM, and 0.066 μM, respectively.

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