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D-JNKI-1

Cat. No. M14157
D-JNKI-1 Structure
Synonym:

AM-111; XG-102

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5mg USD 360  USD360 4-7 Days
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Quality Control & Documentation
Biological Activity

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

Chemical Information
Molecular Weight 3822.44
CAS Number 1445179-97-4
Solubility (25°C) DMSO ≥ 90 mg/mL
Water ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Junling Zhao, et al. The Ameliorative Effect of JNK Inhibitor D-JNKI-1 on Neomycin-Induced Apoptosis in HEI-OC1 Cells

[2] Adrien A Eshraghi, et al. Preclinical and clinical otoprotective applications of cell-penetrating peptide D-JNKI-1 (AM-111)

[3] Sabine Kersting, et al. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium

[4] Yi Zhao, et al. The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

[5] Adrien A Eshraghi, et al. D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma

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Keywords: D-JNKI-1, AM-111; XG-102 supplier, JNK, inhibitors, activators

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