Free shipping on all orders over $ 500

JNK-IN-7

Cat. No. M14158
JNK-IN-7 Structure
Synonym:

JNK inhibitor

Size Price Availability Quantity
5mg USD 325  USD325 In stock
10mg USD 412  USD412 In stock
50mg USD 1100  USD1100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.

Chemical Information
Molecular Weight 493.56
CAS Number 1408064-71-0
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Wu, et al. Sci Rep. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease

Related JNK Products
CC-90001

CC-90001 is a JNK (c-Jun N-terminal kinase) inhibitor that can be used as a Phase II clinical candidate to study idiopathic pulmonary fibrosis.

SU3327

SU3327 is a potent, selective and substrate-competitive JNK inhibitor with an IC50 of 0.7 μM.

L-JNKI-1

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

Juglanin

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities. Juglanin can induce apoptosis and autophagy on human breast cancer cells.

D-JNKI-1

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

  Catalog
Abmole Inhibitor Catalog




Keywords: JNK-IN-7, JNK inhibitor supplier, JNK, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.