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JNK-IN-7

Cat. No. M14158
JNK-IN-7 Structure
Synonym:

JNK inhibitor

Size Price Availability Quantity
1mg USD 175  USD175 In stock
2mg USD 215  USD215 In stock
5mg USD 325  USD325 In stock
10mg USD 412  USD412 In stock
50mg USD 1100  USD1100 In stock
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Quality Control & Documentation
Biological Activity

JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.

Chemical Information
Molecular Weight 493.56
CAS Number 1408064-71-0
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Wu, et al. Sci Rep. Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease

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JNK3 inhibitor-5

JNK3 inhibitor-5 is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM.

JNK-1-IN-1

JNK-1-IN-1 is a JNK-1 inhibitor.

JNK2-IN-1

JNK2-IN-1 is a JNK2 inhibitor (Kds: 79.2 μM).

JNK-1-IN-2

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  Catalog
Abmole Inhibitor Catalog




Keywords: JNK-IN-7, JNK inhibitor supplier, JNK, inhibitors, activators


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