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Cat. No. M2227
Imiquimod Structure

Aldara, R 837

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 35  USD35 In stock
100mg USD 50  USD50 In stock
200mg USD 75  USD75 In stock
500mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Imiquimod acts as a Toll-like receptor 7 (TLR7) agonist. Imiquimod is now an approved treatment for external genital warts caused by human papillomavirus infection.

Product Citations
Chemical Information
Molecular Weight 240.3
Formula C14H16N4
CAS Number 99011-02-6
Solubility (25°C) DMSO 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Bruno O Fonseca, et al. Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial

[2] Jintao Gao, et al. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice

[3] Kai-Cheng Chuang, et al. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells

[4] Jianwei Yuan, et al. Genital warts treatment: Beyond imiquimod

[5] Martin Leverkus. Imiquimod: unexpected killer

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