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Imiquimod

Cat. No. M2227
Imiquimod Structure
Synonym:

Aldara, R 837

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 35  USD35 In stock
100mg USD 50  USD50 In stock
200mg USD 75  USD75 In stock
500mg USD 135  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Imiquimod acts as a Toll-like receptor 7 (TLR7) agonist. Imiquimod is now an approved treatment for external genital warts caused by human papillomavirus infection.

Product Citations
Chemical Information
Molecular Weight 240.3
Formula C14H16N4
CAS Number 99011-02-6
Solubility (25°C) DMSO 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bruno O Fonseca, et al. Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial

[2] Jintao Gao, et al. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice

[3] Kai-Cheng Chuang, et al. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells

[4] Jianwei Yuan, et al. Genital warts treatment: Beyond imiquimod

[5] Martin Leverkus. Imiquimod: unexpected killer

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Keywords: Imiquimod, Aldara, R 837 supplier, TLR, inhibitors, activators

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