About 6 results found for searched term "Imiquimod" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2227 | Imiquimod | Animal Modeling |
| Aldara, R 837; IMQ | ||
| Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity. | ||
| M14128 | Imiquimod hydrochloride | TLR |
| R 837 hydrochloride | ||
| Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. | ||
| M7836 | Hyperforin | TRP Channel |
| Hyperforin is a transient receptor typical 6 (TRPC6) channel activator that regulates Ca2+ levels by activating Ca2+-transducing non-selective typical TRPC6 channels, with antidepressant and antitumor activities. In addition, Hyperforin modulates IL-17α secretion from γδ T cells and ameliorates Imiquimod-induced skin inflammation in psoriasis-like mice. | ||
| M10198 | Zabedosertib | IRAK |
| BAY1834845 | ||
| Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. | ||
| M29661 | BMS-986251 | ROR |
| BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis). | ||
| M54573 | NLRP3-IN-NBC6 | NLR |
| NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. | ||
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