Free shipping on all orders over $ 500

FG-2216 (BIQ)

Cat. No. M8678

All AbMole products are for research use only, cannot be used for human consumption.

FG-2216 (BIQ) Structure
Synonym:

YM-311

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

BIQ (FG-2216) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme. FG-2216 is orally bioavailable and induced significant and reversible Epo induction in vivo. In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.

Chemical Information
Molecular Weight 280.66
Formula C12H9ClN2O4
CAS Number 223387-75-5
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Liesl K Janssens, et al. Sensing an Oxygen Sensor: Development and Application of Activity-Based Assays Directly Monitoring HIF Heterodimerization

[2] Pierre E Signore, et al. A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats

[3] Julia Gnter, et al. Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor

[4] Simon Beuck, et al. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis

[5] Wanja M Bernhardt, et al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD

Related HIF Products
HIF-1α-IN-3 

HIF-1α-IN-3 is a hypoxia-selective HIF-1α inhibitor.

HIF-2α-IN-2 

HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay (SPA).

PRLX-93936 dihydrochloride 

PRLX-93936 dihydrochloride is a HIF-1α inhibitor with anticancer activity.

3-Aminobenzoic acid

3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.

Steppogenin

Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: FG-2216 (BIQ), YM-311 supplier, HIF, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.