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BIQ (FG-2216) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme. FG-2216 is orally bioavailable and induced significant and reversible Epo induction in vivo. In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.
Molecular Weight | 280.66 |
Formula | C12H9ClN2O4 |
CAS Number | 223387-75-5 |
Solubility (25°C) | DMSO: ≥ 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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