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DT2216

Cat. No. M10423

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DT2216 Structure
Synonym:

DT-2216

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 340  USD340 In stock
25mg USD 720  USD720 In stock
50mg USD 1080  USD1080 In stock
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Quality Control & Documentation
Biological Activity

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC). DT2216 targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.

In vivo, DT2216 (i.p.; weekly for 60 days) of 15 mg/kg is more effective at suppressing the growth of MOLT-4 T-ALL xenografts in mice than 7.5 mg/kg.

Product Citations
Chemical Information
Molecular Weight 1542.36
Formula C77H96ClF3N10O10S4
CAS Number 2365172-42-3
Solubility (25°C) DMSO 20 mg/mL
Storage -20°C, sealed
References

[1] Cancer Discov. The PROTAC DT2216 Targets Cancer by Promoting BCL-X L Degradation

[2] Yonghan He, et al. J Hematol Oncol. DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

[3] Sajid Khan, et al. Nat Med. A selective BCL-X L PROTAC degrader achieves safe and potent antitumor activity

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YD23 is a SMARCA2 PROTAC.

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Abmole Inhibitor Catalog




Keywords: DT2216, DT-2216 supplier, PROTAC, inhibitors, activators

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