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Setidegrasib is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib has antitumor effect.
| Molecular Weight | 1117.3 |
| Formula | C60H65FN12O7S |
| CAS Number | 2821793-99-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C, protect from light |
| Related PROTAC Products |
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| ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
| MS4322
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| xStAx-VHLL TFA
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| (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. |
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