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MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively. MZ 1 conjugates the pan-BET inhibitor JQ1 to VH032, a potent and specific VHL ligand, via a 3-unit PEG linker.
| Molecular Weight | 1002.64 |
| Formula | C49H60ClN9O8S2 |
| CAS Number | 1797406-69-9 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | -20°C, dry, sealed, protect from light |
| Related PROTAC Products |
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| Setidegrasib
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| PROTAC HK2 Degrader-1
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| ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
| MS4322
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