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Abmole Inhibitor Catalog 2017

PROTAC Proteolysis Targeting Chimeric Molecules

Inhibitors

Cat.No.  Name Information
M10423 DT2216 DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC).
M10382 PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3.
M10381 TD-165 TD-165 is a PROTAC-based cereblon (CRBN) degrader.
M10380 dBET57 dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2.
M10379 BSJ-03-123 BSJ-03-123 is a novel, potent CDK6-selective small-molecule degrader (PROTAC).
M10067 Ac4GalNAz Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
M9838 VH032-PEG6-C4-Cl (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker.
M9824 MZ 1 MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively.
M9791 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
M9396 A1874 A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells).


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