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Abmole Inhibitor Catalog 2017

PROTAC Proteolysis Targeting Chimeric Molecules


Cat.No.  Name Information
M10135 EGNHS Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent, it is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).
M10067 Ac4GalNAz Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
M9838 VH032-PEG6-C4-Cl (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker.
M9824 MZ 1 MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively.
M9396 A1874 A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells).

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