| Cat.No. | Name | Information |
|---|---|---|
| M40697 | NX-5948 | NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. |
| M10423 | DT2216 | DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. |
| M9396 | A1874 | A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells). |
| M9238 | dBET6 | dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. |
| M8477 | Indisulam | Indisulam is a carbonic anhydrase inibitor and antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition. |
| M7709 | CR8 | CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). |
| M58581 | MS4322 | MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. |
| M58163 | (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine | (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. |
| M57286 | MTX-23 | MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis. |
| M57182 | YD23 | YD23 is a SMARCA2 PROTAC. |
| M57181 | CMP98 | CMP98, a PROTAC, is unable to induce degradation of VHL. |
| M57180 | MS8815 | MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. |
| M57179 | TD-802 | TD-802 is an androgen receptor (AR) PROTAC degrader with good microsomal stability. |
| M57178 | ARD-266 | ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor (AR) PROTAC degrader. |
| M57177 | GNE-987 | GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. |
| M57175 | PhosTAC7 | Similar to PROTACs in their ability to induce ternary complexes, PhosTAC7 focuses on recruiting a Ser/Thr phosphatase to a phosphosubstrate to mediate its dephosphorylation. |
| M57174 | SJ995973 | SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. |
| M57173 | ARD-2585 | ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor. |
| M57172 | XF067-68 | XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). |
| M57171 | SJF-8240 | SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. |
| M57170 | dBRD4-BD1 | dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). |
| M57169 | SB1-G-187 | SB1-G-187, a PROTAC, is a multi-kinase degrader. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
