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PROTAC Proteolysis Targeting Chimeric Molecules

Cat.No.  Name Information
M10384 Homo-PROTAC pVHL30 degrader 1 Homo-PROTAC pVHL30 degrader 1 is a pVHL30 degrader based on PROTAC and a potent VHL inhibitor.
M10383 Homo-PROTAC cereblon degrader 1 (OUN20985) Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3.
M10382 PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3.
M10381 TD-165 TD-165 is a PROTAC-based cereblon (CRBN) degrader.
M10380 dBET57 dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2.
M10379 BSJ-03-123 BSJ-03-123 is a novel, potent CDK6-selective small-molecule degrader (PROTAC).
M10067 Ac4GalNAz Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
M9838 VH032-PEG6-C4-Cl (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker.
M9824 MZ 1 MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively.
M9396 A1874 A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells).
M8477 Indisulam Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor.
M7709 CR8 CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9).
M54696 DGY-09-192 DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells.
M54671 BTX-6654 BTX-6654 is a targeted and specific cerebellar-based bifunctional SOS1 PROTAC degrader.BTX-6654 reduces the downstream signaling markers pERK and pS6 and displays antiproliferative activity in a wide range of KRAS-mutant cells.
M50428 ND1-YL2 ND1-YL2 is a PROTAC that selectively degrades SRC-1 via the N-degron pathway.
M50175 PRT3789 PRT3789 is a PROTAC degrader targeting SMARCA2 with more than 1,000-fold selectivity for SMARCA2 compared to SMARCA4 at the cellular level for studies related to non-small cell lung cancer (NSCLC).
M50174 KT-294 KT-294 is a potential first-in-class, PROTAC protein degrader targeting TYK2 for research related to immune system diseases.
M50173 KT-621 KT-621 is a potential first-in-class, PROTAC protein degrader targeting STAT6 for studies related to immune diseases.
M50171 ARV-102 ARV-102 is a PROTAC degrader targeting LRRK2 for studies related to Parkinson's disease (PD).
M50170 ARV-393 ARV-393 is a PROTAC degrader targeting BCL6 for studies related to diffuse large B-cell lymphoma.




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