Cat.No. | Name | Information |
---|---|---|
M10384 | Homo-PROTAC pVHL30 degrader 1 | Homo-PROTAC pVHL30 degrader 1 is a pVHL30 degrader based on PROTAC and a potent VHL inhibitor. |
M10383 | Homo-PROTAC cereblon degrader 1 (OUN20985) | Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3. |
M10382 | PROTAC SGK3 degrader-1 | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3. |
M10381 | TD-165 | TD-165 is a PROTAC-based cereblon (CRBN) degrader. |
M10380 | dBET57 | dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2. |
M10379 | BSJ-03-123 | BSJ-03-123 is a novel, potent CDK6-selective small-molecule degrader (PROTAC). |
M10067 | Ac4GalNAz | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
M9838 | VH032-PEG6-C4-Cl | (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. |
M9824 | MZ 1 | MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively. |
M9396 | A1874 | A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells). |
M8477 | Indisulam | Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. |
M7709 | CR8 | CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). |
M54696 | DGY-09-192 | DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. |
M54671 | BTX-6654 | BTX-6654 is a targeted and specific cerebellar-based bifunctional SOS1 PROTAC degrader.BTX-6654 reduces the downstream signaling markers pERK and pS6 and displays antiproliferative activity in a wide range of KRAS-mutant cells. |
M50428 | ND1-YL2 | ND1-YL2 is a PROTAC that selectively degrades SRC-1 via the N-degron pathway. |
M50175 | PRT3789 | PRT3789 is a PROTAC degrader targeting SMARCA2 with more than 1,000-fold selectivity for SMARCA2 compared to SMARCA4 at the cellular level for studies related to non-small cell lung cancer (NSCLC). |
M50174 | KT-294 | KT-294 is a potential first-in-class, PROTAC protein degrader targeting TYK2 for research related to immune system diseases. |
M50173 | KT-621 | KT-621 is a potential first-in-class, PROTAC protein degrader targeting STAT6 for studies related to immune diseases. |
M50171 | ARV-102 | ARV-102 is a PROTAC degrader targeting LRRK2 for studies related to Parkinson's disease (PD). |
M50170 | ARV-393 | ARV-393 is a PROTAC degrader targeting BCL6 for studies related to diffuse large B-cell lymphoma. |
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