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Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
| Molecular Weight | 572.53 |
| CAS Number | 1950635-16-1 |
| Solubility (25°C) | DMSO ≥ 131 mg/mL |
| Storage | 2-8°C, dry, sealed |
[1] Shira Joudan, et al. Insufficient evidence for the existence of natural trifluoroacetic acid
[2] Susana P Alves, et al. Trans-10 18:1 in ruminant meats: A review
[4] Jrme Clerc. Radioiodine therapy of thyroid autonomy
[5] Chaoyang Li, et al. Global Surveillance of trans-Fatty Acids
| Related PROTAC Products |
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| CR8
CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). |
| Indisulam
Indisulam is a carbonic anhydrase inibitor and antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition. |
| dBET6
dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. |
| A1874
A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells). |
| MZ 1
MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively. |
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