| Cat.No. | Name | Information |
|---|---|---|
| M40697 | NX-5948 | NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. |
| M10423 | DT2216 | DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. |
| M43451 | SA-PA | SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. |
| M43450 | BI01826025 | BI01826025 (pArg-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. |
| M43449 | SRG-II-19F | SRG-II-19F (dCym-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. |
| M43448 | PROTAC BRD4 Degrader-19 | PROTAC BRD4 Degrader-19 is a PROTAC that targets BRD4 protein for degradation. |
| M43447 | SS47 TFA | SS47 TFA, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. |
| M43446 | PROTAC α-synuclein degrader 3 | PROTAC α-synuclein degrader 3 is a potent and selective PROTAC α-synuclein degrader. |
| M43445 | PROTAC IRAK3 degrade-1 formic | PROTAC IRAK3 degrade-1 formic is a potent and selective degrader of IRAK3 (IC50=5 nM). |
| M43444 | PROTAC ERα Degrader-4 | PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). |
| M43443 | PROTAC NSD3 degrader-1 | PROTAC NSD3 degrader-1 is a PROTAC targeting to Nuclear receptor binding SET domain protein NSD3. |
| M43442 | ARD-2051 | ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. |
| M43441 | PROTAC GPX4 degrader-1 | PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells. |
| M43440 | PROTAC BTK Degrader-3 | PROTAC BTK Degrader-3 is a potent BTK degrader with a DC50 value of 10.9 nM of BTK degradation in Mino cells. |
| M43439 | Dovitinib-RIBOTAC TFA | Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. |
| M43438 | PROTAC TG2 degrader-2 | PROTAC TG2 degrader-2 is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. |
| M43437 | GBD-9 | GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). |
| M43436 | PROTAC TG2 degrader-1 | PROTAC TG2 degrader-1 is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. |
| M43435 | PROTAC BRD4 Degrader-17 | PROTAC BRD4 Degrader-17 is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). |
| M43434 | PROTAC BRD4 Degrader-16 | PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). |
| M43433 | PROTAC BRAF-V600E degrader-2 | PROTAC BRAF-V600E degrader-2 is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. |
| M43432 | SIAIS164018 hydrochloride | SIAIS164018 hydrochloride is a PROTAC-based ALK and EGFR degrader, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. |
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