| Cat.No. | Name | Information |
|---|---|---|
| M40693 | ASP-3082 | ASP-3082 a potent, selective KRAS G12D protein degrader (PROTAC) for solid tumor related studies. |
| M40692 | BGB-16673 | BGB-16673 is an orally active chimeric degradation-activating compound targeting BTK that degrades wild-type BTK and a variety of mutant BTKs, and can be used in studies related to B-cell malignancies as well as non-Hodgkin's lymphoma. |
| M40690 | CC-94676 | CC-94676 is an orally active androgen receptor (AR) degrader for studies related to solid tumors. |
| M40689 | CG001419 | CG001419 is a first-in-class neurotyrosine kinase receptor (TRK) degrader that can be used in a variety of tumor-related studies. |
| M31304 | AU-15330 | AU-15330 is a protein hydrolysis-targeted chimeric (PROTAC) degradation of SWI/SNF ATPase subunits SMARCA2 and SMARCA4, and also induces effective tumor growth inhibition in a prostate cancer xenograft model. |
| M31276 | PROTAC CDK2/9 Degrader-1 | PROTAC CDK2/9 Degrader-1 is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand. |
| M31078 | PROTAC AR Degrader-4 TFA | PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). |
| M31077 | PZ703b TFA | PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research. |
| M31076 | PZ703b hydrochloride | PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research. |
| M31075 | SJF620 hydrochloride | SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. |
| M31074 | CCT367766 formic | CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. |
| M30983 | Chloroquinoxaline sulfonamide | Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity. |
| M29855 | dCeMM2 | dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| M29824 | SZUH280 | SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells. SZUH280 induces cancer cell apoptosis. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization. |
| M29815 | NRX-103094 | NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. |
| M29812 | MS83 | MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder. |
| M29809 | NU223612 | NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB). |
| M29808 | MD13 | MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research. |
| M29804 | XY-06-007 | XY-06-007 is a selective and potent bump-and-hole (B&H)-PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies. |
| M29762 | MS432 | MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively. |
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