| Cat.No. | Name | Information |
|---|---|---|
| M40697 | NX-5948 | NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. |
| M10423 | DT2216 | DT2216 is a BCL-XL protein hydrolysis targeting chimera (PROTAC) that ligates and degrades BCL-XL with E3 ubiquitin (E3) ligase. DT2216 is effective against a variety of BCL-XL-dependent leukemias and cancer cells. |
| M10382 | PROTAC SGK3 degrader-1 | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3. |
| M43457 | PF15 TFA | PF15 TFA is a PROTAC connected by ligands for FLT3 kinase and CRBN. |
| M43456 | ERK-CLIPTAC | ERK-CLIPTAC is a PROTAC molecule that triggers the degradation of ERK. |
| M43455 | Homo-BacPROTAC7 | Homo-BacPROTAC7 is a ClpC1NTD BacPROTAC degrader and can targets ClpC2. |
| M43454 | Homo-BacPROTAC6 | Homo-BacPROTAC6 is a ClpC1NTD BacPROTAC degrader and can targets ClpC2. |
| M43453 | PTD10 | PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). |
| M43452 | SA-VA | SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. |
| M43451 | SA-PA | SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. |
| M43450 | BI01826025 | BI01826025 (pArg-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. |
| M43449 | SRG-II-19F | SRG-II-19F (dCym-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. |
| M43448 | PROTAC BRD4 Degrader-19 | PROTAC BRD4 Degrader-19 is a PROTAC that targets BRD4 protein for degradation. |
| M43447 | SS47 TFA | SS47 TFA, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. |
| M43446 | PROTAC α-synuclein degrader 3 | PROTAC α-synuclein degrader 3 is a potent and selective PROTAC α-synuclein degrader. |
| M43445 | PROTAC IRAK3 degrade-1 formic | PROTAC IRAK3 degrade-1 formic is a potent and selective degrader of IRAK3 (IC50=5 nM). |
| M43444 | PROTAC ERα Degrader-4 | PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). |
| M43443 | PROTAC NSD3 degrader-1 | PROTAC NSD3 degrader-1 is a PROTAC targeting to Nuclear receptor binding SET domain protein NSD3. |
| M43442 | ARD-2051 | ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. |
| M43441 | PROTAC GPX4 degrader-1 | PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells. |
| M43440 | PROTAC BTK Degrader-3 | PROTAC BTK Degrader-3 is a potent BTK degrader with a DC50 value of 10.9 nM of BTK degradation in Mino cells. |
| M43439 | Dovitinib-RIBOTAC TFA | Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. |
| M43438 | PROTAC TG2 degrader-2 | PROTAC TG2 degrader-2 is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. |
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